The Acropolis was built on an extremely steep hill, approached by a winding road ascending some 300m. In this uniquely designed city, religious, official, social and commercial buildings are all found side-by-side. The King of Pergamum is on the top of this hill, which has been inhabited since ancient times. There are also five cisterns and an arsenal on the hill. Below these buildings is the Temple of Athena, as well as the Library and the Temple of Trajan. The Altar of Zeus was carefully placed below these buildings on a terrace.

One of the steepest amphitheatres in the world is found here. The lowest section of the acropolis is the gymnasium and the Temple of Demeter. Because of the topographical location of the city and the course of the main street, all the buildings of the acropolis are line up in a north-south fashion, but the buildings all face west so that they can be seen from far away. The Altar of Zeus was not encircled with colonnades for the same reason. The Agora and Athena Temple also have an unobstructed view of the plain.