The foundation date of Hasankeyf is not known exactly. The geopolitical situation in the city strengthens the possibility of its being a very ancient settlement area. There are lots of caverns some of which are being used even today as residences. In the Christian Era, Hasankeyf experienced the rule of the Sasanis and Byzantines.

Due to a safe castle having been built by the Byzantines in the 4th century BC, the region had been defended by them for a long time. Hasankeyf was conquered by the Emevis in 639 AD. Later on, the Abbasids, Hamdanis, Mervanis, Artuks, Eyyubis and Ottomans ruled the region respectively. The Artuks period was the golden era of Hasankeyf. There are many historical works remaining from this period.